Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

How transcription factor dimerization impacts DNA-binding specificity is poorly understood. Guided by protein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs. DNA interactomes of 80 heterodimers and 22 homodimers revealed that 72% of heterodimer motifs correspo...

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Detalles Bibliográficos
Autores principales: Rodríguez-Martínez, José A, Reinke, Aaron W, Bhimsaria, Devesh, Keating, Amy E, Ansari, Aseem Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349851/
https://www.ncbi.nlm.nih.gov/pubmed/28186491
http://dx.doi.org/10.7554/eLife.19272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349851/
https://www.ncbi.nlm.nih.gov/pubmed/28186491
http://dx.doi.org/10.7554/eLife.19272

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