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Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs

Dysregulated Wnt signalling is associated with human infertility and testicular cancer. However, the role of Wnt signalling in male germ cells remains poorly understood. In this study, we first confirmed the activity of Wnt signalling in mouse, dog and human testes. To determine the physiological im...

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Detalles Bibliográficos
Autores principales: Kumar, Manish, Atkins, Joshua, Cairns, Murray, Ali, Ayesha, Tanwar, Pradeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349868/
https://www.ncbi.nlm.nih.gov/pubmed/27992363
http://dx.doi.org/10.18632/oncotarget.13920