P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors

Carbonic anhydrase XII (CAXII) is a membrane enzyme that maintains pH homeostasis and sustains optimum P-glycoprotein (Pgp) efflux activity in cancer cells. Here, we investigated a panel of eight CAXII inhibitors (compounds 1–8), for their potential to reverse Pgp mediated tumor cell chemoresistance...

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Detalles Bibliográficos
Autores principales: Kopecka, Joanna, Rankin, Gregory M., Salaroglio, Iris C., Poulsen, Sally-Ann, Riganti, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349880/
https://www.ncbi.nlm.nih.gov/pubmed/27811376
http://dx.doi.org/10.18632/oncotarget.13040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349880/
https://www.ncbi.nlm.nih.gov/pubmed/27811376
http://dx.doi.org/10.18632/oncotarget.13040

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