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A regulatory loop involving miR-29c and Sp1 elevates the TGF-β1 mediated epithelial-to-mesenchymal transition in lung cancer

Specificity protein1 (Sp1) is required for TGF-β-induced epithelial-to-mesenchymal transition (EMT) which has been demonstrated to aggravate the progression of cancer including lung cancer. microRNA-29c (miR-29c) is identified to inhibit EMT, but the correlation between miR-29c and Sp1 in human lung...

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Detalles Bibliográficos
Autores principales: Zhang, Hai-wei, Wang, En-wen, Li, Li-xian, Yi, Shou-hui, Li, Lu-chun, Xu, Fa-liang, Wang, Dong-lin, Wu, Yong-zhong, Nian, Wei-qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349884/
https://www.ncbi.nlm.nih.gov/pubmed/27829234
http://dx.doi.org/10.18632/oncotarget.13137