Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

The design and synthesis of a quinazoline-based, multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and other malignancies is reported. Based on the previously reported furanopyrimidine 3, quinazoline core containing lead 4 was synthesized and found to impart dual FLT3/AURKA in...

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Detalles Bibliográficos
Autores principales: Hsu, Yung Chang, Coumar, Mohane Selvaraj, Wang, Wen-Chieh, Shiao, Hui-Yi, Ke, Yi-Yu, Lin, Wen-Hsing, Kuo, Ching-Chuan, Chang, Chun-Wei, Kuo, Fu-Ming, Chen, Pei-Yi, Wang, Sing-Yi, Li, An-Siou, Chen, Chun-Hwa, Kuo, Po-Chu, Chen, Ching-Ping, Wu, Ming-Hsine, Huang, Chen-Lung, Yen, Kuei-Jung, Chang, Yun-I, Hsu, John T.-A., Chen, Chiung-Tong, Yeh, Teng-Kuang, Song, Jen-Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349910/
https://www.ncbi.nlm.nih.gov/pubmed/27863392
http://dx.doi.org/10.18632/oncotarget.13369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349910/
https://www.ncbi.nlm.nih.gov/pubmed/27863392
http://dx.doi.org/10.18632/oncotarget.13369

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