Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation

Cardiac glycosides could increase intracellular Ca(2+) ion by inhibiting the Na(+)/K(+)ATPase to induce apoptosis in many tumor cells. However, narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity hinder their applications in cancer treatment. To improve the safety pro...

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Detalles Bibliográficos
Autores principales: Zhang, Hui-Yun, Xu, Wen-Qian, Zheng, Yuan-yuan, Omari-Siaw, Emmanuel, Zhu, Yuan, Cao, Xia, Tong, Shan-Shan, Yu, Jiang-nan, Xu, Xi-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349917/
https://www.ncbi.nlm.nih.gov/pubmed/27861145
http://dx.doi.org/10.18632/oncotarget.13389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349917/
https://www.ncbi.nlm.nih.gov/pubmed/27861145
http://dx.doi.org/10.18632/oncotarget.13389

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