The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing α(v)β(3) integrin in chick embryo and nude mouse models

Echistatin, a cyclic RGD peptide, which is an antagonist of α(v)β(3) integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model. A high-metastatic variant of human osteosarcoma, 143...

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Detalles Bibliográficos
Autores principales: Tome, Yasunori, Kimura, Hiroaki, Sugimoto, Naotoshi, Tsuchiya, Hiroyuki, Kanaya, Fuminori, Bouvet, Michael, Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349968/
https://www.ncbi.nlm.nih.gov/pubmed/27894082
http://dx.doi.org/10.18632/oncotarget.13497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349968/
https://www.ncbi.nlm.nih.gov/pubmed/27894082
http://dx.doi.org/10.18632/oncotarget.13497

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