Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element

Neuronal nitric oxide synthase is widely regarded as an important contributor to a number of disorders of excitable tissues. Recently the adaptor protein NOS1AP has emerged as a contributor to several nNOS-linked conditions. As a consequence, the unexpectedly complex mechanisms of interaction betwee...

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Detalles Bibliográficos
Autores principales: Li, Li-Li, Cisek, Katryna, Courtney, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350102/
https://www.ncbi.nlm.nih.gov/pubmed/28360833
http://dx.doi.org/10.3389/fnmol.2017.00058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350102/
https://www.ncbi.nlm.nih.gov/pubmed/28360833
http://dx.doi.org/10.3389/fnmol.2017.00058

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