An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts. Understanding how APP is targeted to selected de...

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Detalles Bibliográficos
Autores principales: Poulsen, Ebbe T., Iannuzzi, Filomena, Rasmussen, Helle F., Maier, Thorsten J., Enghild, Jan J., Jørgensen, Arne L., Matrone, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350151/
https://www.ncbi.nlm.nih.gov/pubmed/28360834
http://dx.doi.org/10.3389/fnmol.2017.00059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350151/
https://www.ncbi.nlm.nih.gov/pubmed/28360834
http://dx.doi.org/10.3389/fnmol.2017.00059

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