Inhibition of MAPK‐Erk pathway in vivo attenuates aortic valve disease processes in Emilin1‐deficient mouse model

Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental elastic fiber assembly defects. Emilin1 is a g...

Descripción completa

Detalles Bibliográficos
Autores principales: Munjal, Charu, Jegga, Anil G., Opoka, Amy M., Stoilov, Ivan, Norris, Russell A., Thomas, Craig J., Smith, J. Michael, Mecham, Robert P., Bressan, Giorgio M., Hinton, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350168/
https://www.ncbi.nlm.nih.gov/pubmed/28270590
http://dx.doi.org/10.14814/phy2.13152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350168/
https://www.ncbi.nlm.nih.gov/pubmed/28270590
http://dx.doi.org/10.14814/phy2.13152

Ejemplares similares