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Inhibition of MAPK‐Erk pathway in vivo attenuates aortic valve disease processes in Emilin1‐deficient mouse model

Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental elastic fiber assembly defects. Emilin1 is a g...

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Detalles Bibliográficos
Autores principales:	Munjal, Charu, Jegga, Anil G., Opoka, Amy M., Stoilov, Ivan, Norris, Russell A., Thomas, Craig J., Smith, J. Michael, Mecham, Robert P., Bressan, Giorgio M., Hinton, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350168/ https://www.ncbi.nlm.nih.gov/pubmed/28270590 http://dx.doi.org/10.14814/phy2.13152

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