Antibody‐mediated inhibition of EGFR reduces phosphate excretion and induces hyperphosphatemia and mild hypomagnesemia in mice

Monoclonal antibody therapies targeting the EGF receptor (EGFR) frequently result in hypomagnesemia in human patients. In contrast, EGFR tyrosine kinase inhibitors do not affect Mg(2+) balance in patients and only have a mild effect on Mg(2+) homeostasis in rodents at elevated doses. EGF has also be...

Descripción completa

Detalles Bibliográficos
Autores principales: Ortega, Bernardo, Dey, Jason M., Gardella, Allison R., Proano, Jacob, Vaneerde, Deanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Orginial Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350180/
https://www.ncbi.nlm.nih.gov/pubmed/28292888
http://dx.doi.org/10.14814/phy2.13176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350180/
https://www.ncbi.nlm.nih.gov/pubmed/28292888
http://dx.doi.org/10.14814/phy2.13176

Ejemplares similares