Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension

Objective. Oxidative stress and endothelial dysfunction contribute to pulmonary arterial hypertension (PAH). The role of the nitrovasodilator pentaerythritol tetranitrate (PETN) on endothelial function and oxidative stress in PAH has not yet been defined. Methods and Results. PAH was induced by mono...

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Detalles Bibliográficos
Autores principales: Steven, Sebastian, Oelze, Matthias, Brandt, Moritz, Ullmann, Elisabeth, Kröller-Schön, Swenja, Heeren, Tjebo, Tran, Lan P., Daub, Steffen, Dib, Mobin, Stalleicken, Dirk, Wenzel, Philip, Münzel, Thomas, Daiber, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350298/
https://www.ncbi.nlm.nih.gov/pubmed/28337251
http://dx.doi.org/10.1155/2017/4353462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350298/
https://www.ncbi.nlm.nih.gov/pubmed/28337251
http://dx.doi.org/10.1155/2017/4353462

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