Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature

Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobilit...

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Detalles Bibliográficos
Autores principales: Jiang, Youde, Liu, Li, Curtiss, Elizabeth, Steinle, Jena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350318/
https://www.ncbi.nlm.nih.gov/pubmed/28348460
http://dx.doi.org/10.1155/2017/2860956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350318/
https://www.ncbi.nlm.nih.gov/pubmed/28348460
http://dx.doi.org/10.1155/2017/2860956

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