AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin

Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth. Knockdown of LPA receptor 1 (LPA1) has been shown to mitigate lung injury and pulmonary fibrosis...

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Detalles Bibliográficos
Autores principales: Cai, Junting, Wei, Jianxin, Li, Shuang, Suber, Tomeka, Zhao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350330/
https://www.ncbi.nlm.nih.gov/pubmed/28348461
http://dx.doi.org/10.1155/2017/6893560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350330/
https://www.ncbi.nlm.nih.gov/pubmed/28348461
http://dx.doi.org/10.1155/2017/6893560

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