Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A(2A)R signaling

Bone homeostasis depends on the functional balance of osteoblasts (OBs) and osteoclasts (OCs). Lrp4 is a transmembrane protein that is mutated in patients with high bone mass. Loss of Lrp4 in OB-lineage cells increases bone mass by elevating bone formation by OBs and reducing bone resorption by OCs....

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Detalles Bibliográficos
Autores principales: Xiong, Lei, Jung, Ji-Ung, Guo, Hao-Han, Pan, Jin-Xiu, Sun, Xiang-Dong, Mei, Lin, Xiong, Wen-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350517/
https://www.ncbi.nlm.nih.gov/pubmed/28193701
http://dx.doi.org/10.1083/jcb.201608002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350517/
https://www.ncbi.nlm.nih.gov/pubmed/28193701
http://dx.doi.org/10.1083/jcb.201608002

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