Importin-11 keeps PTEN safe from harm

In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN...

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Detalles Bibliográficos
Autor principal: Leslie, Nick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350522/
https://www.ncbi.nlm.nih.gov/pubmed/28193699
http://dx.doi.org/10.1083/jcb.201612014
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author Leslie, Nick R.
author_facet Leslie, Nick R.
author_sort Leslie, Nick R.
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description In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.
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spelling pubmed-53505222017-09-06 Importin-11 keeps PTEN safe from harm Leslie, Nick R. J Cell Biol Commentary In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor. The Rockefeller University Press 2017-03-06 /pmc/articles/PMC5350522/ /pubmed/28193699 http://dx.doi.org/10.1083/jcb.201612014 Text en © 2017 Leslie http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Leslie, Nick R.
Importin-11 keeps PTEN safe from harm
title Importin-11 keeps PTEN safe from harm
title_full Importin-11 keeps PTEN safe from harm
title_fullStr Importin-11 keeps PTEN safe from harm
title_full_unstemmed Importin-11 keeps PTEN safe from harm
title_short Importin-11 keeps PTEN safe from harm
title_sort importin-11 keeps pten safe from harm
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350522/
https://www.ncbi.nlm.nih.gov/pubmed/28193699
http://dx.doi.org/10.1083/jcb.201612014
work_keys_str_mv AT leslienickr importin11keepsptensafefromharm

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