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Importin-11 keeps PTEN safe from harm

In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN...

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Detalles Bibliográficos
Autor principal: Leslie, Nick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350522/
https://www.ncbi.nlm.nih.gov/pubmed/28193699
http://dx.doi.org/10.1083/jcb.201612014