A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage

DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1(Dpb11) provides binding sites for both pro- an...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimada, Kenji, Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350523/
https://www.ncbi.nlm.nih.gov/pubmed/28235945
http://dx.doi.org/10.1083/jcb.201701038
_version_ 1782514680302927872
author Shimada, Kenji
Gasser, Susan M.
author_facet Shimada, Kenji
Gasser, Susan M.
author_sort Shimada, Kenji
collection PubMed
description DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1(Dpb11) provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation.
format Online
Article
Text
id pubmed-5350523
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-53505232017-09-06 A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage Shimada, Kenji Gasser, Susan M. J Cell Biol Commentary DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1(Dpb11) provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation. The Rockefeller University Press 2017-03-06 /pmc/articles/PMC5350523/ /pubmed/28235945 http://dx.doi.org/10.1083/jcb.201701038 Text en © 2017 Shimada and Gasser http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Shimada, Kenji
Gasser, Susan M.
A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title_full A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title_fullStr A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title_full_unstemmed A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title_short A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage
title_sort game of musical chairs: pro- and anti-resection factors compete for topbp1 binding after dna damage
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350523/
https://www.ncbi.nlm.nih.gov/pubmed/28235945
http://dx.doi.org/10.1083/jcb.201701038
work_keys_str_mv AT shimadakenji agameofmusicalchairsproandantiresectionfactorscompetefortopbp1bindingafterdnadamage
AT gassersusanm agameofmusicalchairsproandantiresectionfactorscompetefortopbp1bindingafterdnadamage
AT shimadakenji gameofmusicalchairsproandantiresectionfactorscompetefortopbp1bindingafterdnadamage
AT gassersusanm gameofmusicalchairsproandantiresectionfactorscompetefortopbp1bindingafterdnadamage

Ejemplares similares