The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family

Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to...

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Detalles Bibliográficos
Autores principales: Chipuk, Jerry Edward, Luna-Vargas, Mark P.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350527/
https://www.ncbi.nlm.nih.gov/pubmed/28193702
http://dx.doi.org/10.1083/jcb.201701187
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author Chipuk, Jerry Edward
Luna-Vargas, Mark P.A.
author_facet Chipuk, Jerry Edward
Luna-Vargas, Mark P.A.
author_sort Chipuk, Jerry Edward
collection PubMed
description Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.
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spelling pubmed-53505272017-09-06 The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family Chipuk, Jerry Edward Luna-Vargas, Mark P.A. J Cell Biol Commentary Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins. The Rockefeller University Press 2017-03-06 /pmc/articles/PMC5350527/ /pubmed/28193702 http://dx.doi.org/10.1083/jcb.201701187 Text en © 2017 Chipuk and Luna-Vargas http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Chipuk, Jerry Edward
Luna-Vargas, Mark P.A.
The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title_full The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title_fullStr The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title_full_unstemmed The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title_short The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
title_sort peroxisomes strike bak: regulation of peroxisome integrity by the bcl-2 family
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350527/
https://www.ncbi.nlm.nih.gov/pubmed/28193702
http://dx.doi.org/10.1083/jcb.201701187
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