Cargando…

Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model

In higher eukaryotes, cell proliferation is regulated by class I phosphatidylinositol 3-kinase (PI3K), which transduces stimuli received from neighboring receptors by local generation of PtdIns(3,4,5)P(3) in cellular membranes. PI3K is a heterodimeric protein consisting of a regulatory and a catalyt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliver, María D., Fernández-Acero, Teresa, Luna, Sandra, Rodríguez-Escudero, Isabel, Molina, María, Pulido, Rafael, Cid, Víctor J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350601/ https://www.ncbi.nlm.nih.gov/pubmed/28143957 http://dx.doi.org/10.1042/BSR20160258

Ejemplares similares

A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels
por: Coronas-Serna, Julia María, et al.
Publicado: (2018)

Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function
por: Fernández-Acero, Teresa, et al.
Publicado: (2019)

Neomycin Interferes with Phosphatidylinositol-4,5-Bisphosphate at the Yeast Plasma Membrane and Activates the Cell Wall Integrity Pathway
por: Jiménez-Gutiérrez, Elena, et al.
Publicado: (2022)

Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae
por: Rodríguez-Escudero, Isabel, et al.
Publicado: (2018)

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017)

Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity
por: Chaudhari, Aditi, et al.
Publicado: (2018)

Structure of 85 kDa Subunit of Human Phosphatidylinositol 3‐Kinase Analyzed by Using Monoclonal Antibodies
por: Tanaka, Shinya, et al.
Publicado: (1993)

A Functional Dissection of PTEN N-Terminus: Implications in PTEN Subcellular Targeting and Tumor Suppressor Activity
por: Gil, Anabel, et al.
Publicado: (2015)

Studying Coxiella burnetii Type IV Substrates in the Yeast Saccharomyces cerevisiae: Focus on Subcellular Localization and Protein Aggregation
por: Rodríguez-Escudero, María, et al.
Publicado: (2016)

Structural basis of phosphatidylinositol 3-kinase C2α function
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα
por: Zhou, Qiangjun, et al.
Publicado: (2014)

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Enhanced Cell Killing by Overexpression of Dominant‐negative Phosphatidylinositol 3‐Kinase Subunit, Δp85, Following Genotoxic Stresses
por: Tachiiri, Seiji, et al.
Publicado: (2000)

Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus
por: Strahl, Thomas, et al.
Publicado: (2005)

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α
por: Sasaki, Junko, et al.
Publicado: (2005)

Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
por: Folgiero, V, et al.
Publicado: (2012)

Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification
por: Valer, José Antonio, et al.
Publicado: (2019)

Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
por: Raunio, Anna, et al.
Publicado: (2017)

Insight into the PTEN – p85α interaction and lipid binding properties of the p85α BH domain
por: Marshall, Jeremy D.S., et al.
Publicado: (2018)

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication
por: Delang, Leen, et al.
Publicado: (2012)

Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity
por: González-Rubio, Gema, et al.
Publicado: (2022)

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
por: Nakada-Tsukui, Kumiko, et al.
Publicado: (2019)

Exploring phosphatidylinositol 5-phosphate 4-kinase function
por: Bulley, Simon J., et al.
Publicado: (2015)

Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation
por: Thi, Emily P., et al.
Publicado: (2012)

Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2010)

Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation
por: González-Rubio, Gema, et al.
Publicado: (2019)

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours
por: CAPODANNO, ALESSANDRA, et al.
Publicado: (2012)

Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria
por: McNamara, Case W, et al.
Publicado: (2013)

Fluconazole‐induced actin cytoskeleton remodeling requires phosphatidylinositol 3‐phosphate 5‐kinase in the pathogenic yeast Candida glabrata
por: Bhakt, Priyanka, et al.
Publicado: (2018)

Phosphoinositide 3-kinase p85beta regulates invadopodium formation
por: Cariaga-Martínez, Ariel E., et al.
Publicado: (2014)

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
Publicado: (1995)

Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
por: Valenti, Marta, et al.
Publicado: (2023)

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
por: Kent, Lindsey N, et al.
Publicado: (2010)

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
por: Baskaran, Sulochanadevi, et al.
Publicado: (2014)

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome
por: Cohen, Jeffrey I.
Publicado: (2018)

The Role of Phosphatidylinositol Phosphate Kinases during Viral Infection
por: Beziau, Anne, et al.
Publicado: (2020)

Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia
por: Goncalves, Marcus D., et al.
Publicado: (2022)

Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases
por: Berryman, Stephen, et al.
Publicado: (2016)

A novel phosphatidylinositol(3,4,5)P(3) pathway in fission yeast
por: Mitra, Prasenjit, et al.
Publicado: (2004)

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K(2P) background K(+) channel TASK-2
por: Niemeyer, María Isabel, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3bmje4p5851tt8drcips7kspq4