Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants

The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH. d‐MPH plasma concentrations, demographic covariates, and carboxylester...

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Detalles Bibliográficos
Autores principales: Lyauk, YK, Stage, C, Bergmann, TK, Ferrero‐Milliani, L, Bjerre, D, Thomsen, R, Dalhoff, KP, Rasmussen, HB, Jürgens, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351003/
https://www.ncbi.nlm.nih.gov/pubmed/27754602
http://dx.doi.org/10.1111/cts.12423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351003/
https://www.ncbi.nlm.nih.gov/pubmed/27754602
http://dx.doi.org/10.1111/cts.12423

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