Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage

Obeticholic acid (OCA), a semisynthetic bile acid, is a selective and potent farnesoid X receptor (FXR) agonist in development for the treatment of chronic nonviral liver diseases. Physiologic pharmacokinetic models have been previously used to describe the absorption, distribution, metabolism, and...

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Detalles Bibliográficos
Autores principales: Edwards, JE, LaCerte, C, Peyret, T, Gosselin, NH, Marier, JF, Hofmann, AF, Shapiro, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351006/
https://www.ncbi.nlm.nih.gov/pubmed/27743502
http://dx.doi.org/10.1111/cts.12421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351006/
https://www.ncbi.nlm.nih.gov/pubmed/27743502
http://dx.doi.org/10.1111/cts.12421

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