Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation causes morphological and/or functional changes at nigro-striatal dopamine neurons. Density of striatal dopaminergic terminals,...

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Detalles Bibliográficos
Autores principales: Longo, Francesco, Mercatelli, Daniela, Novello, Salvatore, Arcuri, Ludovico, Brugnoli, Alberto, Vincenzi, Fabrizio, Russo, Isabella, Berti, Giulia, Mabrouk, Omar S., Kennedy, Robert T., Shimshek, Derya R., Varani, Katia, Bubacco, Luigi, Greggio, Elisa, Morari, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351259/
https://www.ncbi.nlm.nih.gov/pubmed/28292328
http://dx.doi.org/10.1186/s40478-017-0426-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351259/
https://www.ncbi.nlm.nih.gov/pubmed/28292328
http://dx.doi.org/10.1186/s40478-017-0426-8

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