CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole-genome sequencing data

BACKGROUND: Copy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These aberrations are continuously accumulated during the procedure of clonal evolution and patterned by phylogenetic branching. This invariably...

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Detalles Bibliográficos
Autores principales: Yu, Zhenhua, Li, Ao, Wang, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351278/
https://www.ncbi.nlm.nih.gov/pubmed/28298214
http://dx.doi.org/10.1186/s12920-017-0255-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351278/
https://www.ncbi.nlm.nih.gov/pubmed/28298214
http://dx.doi.org/10.1186/s12920-017-0255-4

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