Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer

PAX8-PPARG fusion protein (PPFP) results from a t(2;3)(q13;p25) chromosomal translocation, is found in 30% of follicular thyroid carcinomas, and demonstrates oncogenic capacity in transgenic mice. A PPARG ligand, pioglitazone, is highly therapeutic in mice with PPFP thyroid cancer. However, only lim...

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Detalles Bibliográficos
Autores principales: Zhang, Yanxiao, Yu, Jingcheng, Grachtchouk, Vladimir, Qin, Tingting, Lumeng, Carey N, Sartor, Maureen A, Koenig, Ronald J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351587/
https://www.ncbi.nlm.nih.gov/pubmed/28008156
http://dx.doi.org/10.18632/oncotarget.14050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351587/
https://www.ncbi.nlm.nih.gov/pubmed/28008156
http://dx.doi.org/10.18632/oncotarget.14050

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