Cargando…

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts

Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoover, Malachia, Adamian, Yvess, Brown, Mark, Maawy, Ali, Chang, Alexander, Lee, Jacqueline, Gharibi, Armen, Katz, Matthew H, Fleming, Jason, Hoffman, Robert M, Bouvet, Michael, Doebler, Robert, Kelber, Jonathan A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351598/ https://www.ncbi.nlm.nih.gov/pubmed/27602776 http://dx.doi.org/10.18632/oncotarget.11809

Ejemplares similares

ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer
por: Gharibi, Armen, et al.
Publicado: (2017)

Ascending the PEAK1 toward targeting TGFβ during cancer progression: Recent advances and future perspectives
por: Runa, Farhana, et al.
Publicado: (2016)

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery
por: Yano, Shuya, et al.
Publicado: (2015)

Metastatic Recurrence in a Pancreatic Cancer Patient Derived Orthotopic Xenograft (PDOX) Nude Mouse Model Is Inhibited by Neoadjuvant Chemotherapy in Combination with Fluorescence-Guided Surgery with an Anti-CA 19-9-Conjugated Fluorophore
por: Hiroshima, Yukihiko, et al.
Publicado: (2014)

MUC1 Selectively Targets Human Pancreatic Cancer in Orthotopic Nude Mouse Models
por: Park, Jeong Youp, et al.
Publicado: (2015)

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma †
por: Hoffman, Robert M.
Publicado: (2017)

Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern
por: Hiroshima, Yukihiko, et al.
Publicado: (2015)

Near Infra-Red Photoimmunotherapy with Anti-CEA-IR700 Results in Extensive Tumor Lysis and a Significant Decrease in Tumor Burden in Orthotopic Mouse Models of Pancreatic Cancer
por: Maawy, Ali A., et al.
Publicado: (2015)

Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy
por: Hiroshima, Yukihiko, et al.
Publicado: (2016)

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts
por: Fung, Andrea S, et al.
Publicado: (2015)

Identification and causes of metabonomic difference between orthotopic and subcutaneous xenograft of pancreatic cancer
por: Zhan, Bohan, et al.
Publicado: (2017)

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models
por: Hiroshima, Yukihiko, et al.
Publicado: (2014)

Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor Resistance
por: Geller, Cameron, et al.
Publicado: (2023)

Difference in morphology and interactome profiles between orthotopic and subcutaneous gastric cancer xenograft models
por: Nakano, Kiyotaka, et al.
Publicado: (2018)

Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model
por: Zhu, Guangwei, et al.
Publicado: (2020)

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model
por: Yamamoto, Mako, et al.
Publicado: (2016)

Different tumorigenicity and distinct metastasis and gene signature between orthotopic and subcutaneous neuroblastoma xenografted mice
por: Han, Rui, et al.
Publicado: (2022)

Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models
por: da Costa, Maria Eugenia Marques, et al.
Publicado: (2023)

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)
por: Kawaguchi, Kei, et al.
Publicado: (2017)

Fluorescence-Guided Surgery in Combination with UVC Irradiation Cures Metastatic Human Pancreatic Cancer in Orthotopic Mouse Models
por: Hiroshima, Yukihiko, et al.
Publicado: (2014)

The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model
por: Higuchi, Takashi, et al.
Publicado: (2019)

Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse models
por: Hollandsworth, Hannah M., et al.
Publicado: (2020)

SimFFPE and FilterFFPE: improving structural variant calling in FFPE samples
por: Wei, Lanying, et al.
Publicado: (2021)

Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer
por: Snyder, Cynthia S, et al.
Publicado: (2009)

Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application
por: Higuchi, Takashi, et al.
Publicado: (2022)

Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model
por: Lwin, Thinzar M., et al.
Publicado: (2018)

Noninvasive Bioluminescence Imaging of AKT Kinase Activity in Subcutaneous and Orthotopic NSCLC Xenografts: Correlation of AKT Activity with Tumor Growth Kinetics()
por: Suchowski, Karina, et al.
Publicado: (2017)

Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models
por: Murakami, Takashi, et al.
Publicado: (2015)

PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer
por: Agajanian, Megan, et al.
Publicado: (2015)

Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) Dyes Conjugated to Chimeric Anti-Carcinoembryonic Antigen (CEA) Antibody Enhances Imaging of Liver Metastases in a Nude-Mouse Model of Human Colon Cancer
por: Maawy, Ali A., et al.
Publicado: (2014)

Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model
por: Murakami, Takashi, et al.
Publicado: (2017)

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
por: Jäger, Wolfgang, et al.
Publicado: (2014)

Development and characterization of a human orthotopic neuroblastoma xenograft
por: Stewart, Elizabeth, et al.
Publicado: (2015)

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors
por: Stewart, Elizabeth, et al.
Publicado: (2017)

Orthotopic tumours, a hot topic for xenograft models?
por: Zheng, Dali
Publicado: (2019)

Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors
por: Jun, Eunsung, et al.
Publicado: (2017)

Metronomic Gemcitabine in Combination with Sunitinib Inhibits Multisite Metastasis and Increases Survival in an Orthotopic Model of Pancreatic Cancer
por: Tran Cao, Hop S., et al.
Publicado: (2010)

Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models
por: Hollandsworth, Hannah M., et al.
Publicado: (2020)

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model
por: Murakami, Takashi, et al.
Publicado: (2016)

Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
por: Kawaguchi, Kei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rppbeonfhi6ndrfef898svjini