Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

Recent studies have shown that high ATP levels exhibit direct cytotoxic effects on several cancer cells types. Among the receptors engaged by ATP, P2×7R is the most consistently expressed by tumors. P2×7R is an ATP-gated ion channel that could drive the opening of a non-selective pore, triggering ce...

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Detalles Bibliográficos
Autores principales: Salvestrini, Valentina, Orecchioni, Stefania, Talarico, Giovanna, Reggiani, Francesca, Mazzetti, Cristina, Bertolini, Francesco, Orioli, Elisa, Adinolfi, Elena, Virgilio, Francesco Di, Pezzi, Annalisa, Cavo, Michele, Lemoli, Roberto M, Curti, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351599/
https://www.ncbi.nlm.nih.gov/pubmed/27980223
http://dx.doi.org/10.18632/oncotarget.13927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351599/
https://www.ncbi.nlm.nih.gov/pubmed/27980223
http://dx.doi.org/10.18632/oncotarget.13927

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