The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that promotes G2/M-phase transition, is expressed in elevated levels in high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we and others have presented PLK1 as a potential drug target for neuroblastoma, and repor...

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Detalles Bibliográficos
Autores principales: Pajtler, Kristian W, Sadowski, Natalie, Ackermann, Sandra, Althoff, Kristina, Schönbeck, Kerstin, Batzke, Katharina, Sch, Simonäfers, Odersky, Andrea, Heukamp, Lukas, Astrahantseff, Kathy, Künkele, Annette, Deubzer, Hedwig E, Schramm, Alexander, Spr, Annikaüssel, Thor, Theresa, Lindner, Sven, Eggert, Angelika, Fischer, Matthias, Schulte, Johannes H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351666/
https://www.ncbi.nlm.nih.gov/pubmed/28036269
http://dx.doi.org/10.18632/oncotarget.14268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351666/
https://www.ncbi.nlm.nih.gov/pubmed/28036269
http://dx.doi.org/10.18632/oncotarget.14268

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