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Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

Zoledronic acid (ZA) is a biphosphonate used for osteoporosis treatment and also proved to be effective to reduce the pain induced by bone metastases when used as adjuvant therapy in solid cancers. However, it has been recently proposed that ZA could have direct anti-tumour effects, although the mol...

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Detalles Bibliográficos
Autores principales: Comito, Giuseppina, Segura, Coral Pons, Taddei, Maria Letizia, Lanciotti, Michele, Serni, Sergio, Morandi, Andrea, Chiarugi, Paola, Giannoni, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352046/
https://www.ncbi.nlm.nih.gov/pubmed/27223431
http://dx.doi.org/10.18632/oncotarget.9497