4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression

Estrogen (17β-estradiol, E(2)) undergoes oxidative metabolism by CYP1B1 to form 4-hydroxyestradiol (4-OHE(2)), a putative carcinogenic metabolite of estrogen. Our previous study showed that 4-OHE(2)-induced production of reactive oxygen species contributed to neoplastic transformation of human breas...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Sin-Aye, Lee, Mee-Hyun, Na, Hye-Kyung, Surh, Young-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352084/
https://www.ncbi.nlm.nih.gov/pubmed/27438141
http://dx.doi.org/10.18632/oncotarget.10516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352084/
https://www.ncbi.nlm.nih.gov/pubmed/27438141
http://dx.doi.org/10.18632/oncotarget.10516

Ejemplares similares