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4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression
Estrogen (17β-estradiol, E(2)) undergoes oxidative metabolism by CYP1B1 to form 4-hydroxyestradiol (4-OHE(2)), a putative carcinogenic metabolite of estrogen. Our previous study showed that 4-OHE(2)-induced production of reactive oxygen species contributed to neoplastic transformation of human breas...
Autores principales: | Park, Sin-Aye, Lee, Mee-Hyun, Na, Hye-Kyung, Surh, Young-Joon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352084/ https://www.ncbi.nlm.nih.gov/pubmed/27438141 http://dx.doi.org/10.18632/oncotarget.10516 |
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