IGFBP2 expression predicts IDH-mutant glioma patient survival

Mutations of the isocitrate dehydrogenase (IDH) 1 and 2 genes occur in ~80% of lower-grade (WHO grade II and grade III) gliomas. Mutant IDH produces (R)-2-hydroxyglutarate, which induces DNA hypermethylation and presumably drives tumorigenesis. Interestingly, IDH mutations are associated with improv...

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Detalles Bibliográficos
Autores principales: Huang, Lin Eric, Cohen, Adam L., Colman, Howard, Jensen, Randy L., Fults, Daniel W., Couldwell, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352106/
https://www.ncbi.nlm.nih.gov/pubmed/27852048
http://dx.doi.org/10.18632/oncotarget.13329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352106/
https://www.ncbi.nlm.nih.gov/pubmed/27852048
http://dx.doi.org/10.18632/oncotarget.13329

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