Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade

Death Receptor 5 (DR5) is known to be an important anti-cancer drug target. TRAIL is a natural ligand of DR5, but its drug action is limited because of several factors. A few agonistic ligands were identified as TRAIL-DR5 axis modulators, which enhance the cellular apoptosis. Literature suggest that...

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Detalles Bibliográficos
Autores principales: Das, Sarita, Tripathi, Neha, Preet, Ranjan, Siddharth, Sumit, Nayak, Anmada, Bharatam, Prasad V., Kundu, Chanakya Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352116/
https://www.ncbi.nlm.nih.gov/pubmed/27542249
http://dx.doi.org/10.18632/oncotarget.11335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352116/
https://www.ncbi.nlm.nih.gov/pubmed/27542249
http://dx.doi.org/10.18632/oncotarget.11335

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