Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis

Colitis associated cancer (CAC) is chronic inflammation driven colon cancer, prevalent among individuals with Inflammatory Bowel Disease. Matrix-metalloproteinase (MMP9) is one of the essential regulators of extra cellular matrix components. We have shown that MMP9 is protective in CAC contrary to i...

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Detalles Bibliográficos
Autores principales: Walter, Lewins, Pujada, Adani, Bhatnagar, Noopur, Bialkowska, Agnieszka B, Yang, Vincent W., Laroui, Hamed, Garg, Pallavi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352126/
https://www.ncbi.nlm.nih.gov/pubmed/27861153
http://dx.doi.org/10.18632/oncotarget.13406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352126/
https://www.ncbi.nlm.nih.gov/pubmed/27861153
http://dx.doi.org/10.18632/oncotarget.13406

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