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Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression

Although previous studies suggested that microRNA-506-3p (miR-506-3p) was frequently downregulated, and functioned as a tumor suppressor in several cancers, the biological role and intrinsic regulatory mechanisms of miR-506-3p in non-small cell lung cancer (NSCLC) remain elusive. The present study f...

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Detalles Bibliográficos
Autores principales: Guo, Shanqi, Yang, Peiying, Jiang, Xingkang, Li, Xiaojiang, Wang, Yuanyuan, Zhang, Xin, Sun, Binxu, Zhang, Yao, Jia, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352185/
https://www.ncbi.nlm.nih.gov/pubmed/27893417
http://dx.doi.org/10.18632/oncotarget.13501