Cargando…

Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling

Retinopathy of prematurity (ROP) is characterized by late-phase pathologic retinal vasoproliferation. Gremlin is a novel vascular endothelial growth factors (VEGF) receptor 2 (VEGFR2) agonist and promotes angiogenic response. We demonstrated that gremlin expression was significantly increased in ret...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yuan, Chen, Zhijun, Cheng, Haixia, Chen, Juan, Qian, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352211/ https://www.ncbi.nlm.nih.gov/pubmed/27894090 http://dx.doi.org/10.18632/oncotarget.13518

Ejemplares similares

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway
por: Hu, He, et al.
Publicado: (2018)

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
por: Huang, Jiancheng, et al.
Publicado: (2019)

Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
por: Qin, Dong, et al.
Publicado: (2020)

DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium
por: Cai, Jiyang, et al.
Publicado: (2022)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Lutein Inhibits the Migration of Retinal Pigment Epithelial Cells via Cytosolic and Mitochondrial Akt Pathways (Lutein Inhibits RPE Cells Migration)
por: Su, Ching-Chieh, et al.
Publicado: (2014)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
por: Chen, Qiongfeng, et al.
Publicado: (2022)

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
por: Guenzle, Jessica, et al.
Publicado: (2020)

Age-Related Changes in the Retinal Pigment Epithelium (RPE)
por: Gu, Xiaorong, et al.
Publicado: (2012)

Proteomics of Human Retinal Pigment Epithelium (RPE) Cells
por: Beranova-Giorgianni, Sarka, et al.
Publicado: (2018)

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
por: Xu, Ke, et al.
Publicado: (2017)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
por: Chen, Yingji, et al.
Publicado: (2023)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
por: Brown, Emily E., et al.
Publicado: (2019)

mTORC1 sustains vision in retinitis pigmentosa
por: Petit, Lolita, et al.
Publicado: (2015)

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium
por: Dellinger, Michael T., et al.
Publicado: (2011)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT
por: Mecca, Carmen, et al.
Publicado: (2018)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling
por: Ji, Chao, et al.
Publicado: (2016)

Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration
por: DeRamus, Marci L., et al.
Publicado: (2020)

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis
por: Marquez-Exposito, Laura, et al.
Publicado: (2018)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling
por: Zhu, Mengjing, et al.
Publicado: (2022)

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
por: Zhang, Hui H., et al.
Publicado: (2009)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
por: Martinez, Nuria, et al.
Publicado: (2019)

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
por: Salazar, María, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eloba3sg4pkpn3b6tf9kfrsual