Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is persistently activated in many human tumors including acute myeloid leukemia (AML). Therefore, inhibition of Nrf2 activity may be a promising target in leukemia therapy. Here, we used an antioxidant response element-luciferase reporter system to...

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Detalles Bibliográficos
Autores principales: Zhang, JinFeng, Su, Le, Ye, Qing, Zhang, ShangLi, Kung, HsiangFu, Jiang, Fan, Jiang, GuoSheng, Miao, JunYing, Zhao, BaoXiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352348/
https://www.ncbi.nlm.nih.gov/pubmed/28032588
http://dx.doi.org/10.18632/oncotarget.13825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352348/
https://www.ncbi.nlm.nih.gov/pubmed/28032588
http://dx.doi.org/10.18632/oncotarget.13825

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