Cargando…

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

Hepatocellular carcinoma is associated with a high rate of intra-hepatic invasion that carries a poor prognosis. Meprin alpha (Mep1A) is a secreted metalloproteinase with many substrates relevant to cancer invasion. We found that Mep1A was a target of Reptin, a protein that is oncogenic in HCC. We s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Breig, Osman, Yates, Maïlyn, Neaud, Véronique, Couchy, Gabrielle, Grigoletto, Aude, Lucchesi, Carlo, Prox, Johannes, Zucman-Rossi, Jessica, Becker-Pauly, Christoph, Rosenbaum, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352365/ https://www.ncbi.nlm.nih.gov/pubmed/27999200 http://dx.doi.org/10.18632/oncotarget.13975

Ejemplares similares

Reptin Regulates DNA Double Strand Breaks Repair in Human Hepatocellular Carcinoma
por: Raymond, Anne-Aurélie, et al.
Publicado: (2015)

Discovery of a novel ligand that modulates the protein–protein interactions of the AAA+ superfamily oncoprotein reptin
por: Healy, Alan R., et al.
Publicado: (2015)

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
por: Broder, Claudia, et al.
Publicado: (2013)

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
por: Karmilin, Konstantin, et al.
Publicado: (2019)

Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin β
por: Martin, Barry Lee, et al.
Publicado: (2016)

The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology
por: Mao, Yu-Qian, et al.
Publicado: (2017)

Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII
por: Kruppa, Daniel, et al.
Publicado: (2021)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
por: Jefferson, Tamara, et al.
Publicado: (2012)

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
por: Schönherr, Caroline, et al.
Publicado: (2016)

The putative pleiotropic functions of meprin β in gastric cancer
por: Siemsen, Wiebke, et al.
Publicado: (2023)

The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors
por: Matias, Pedro M., et al.
Publicado: (2015)

Meprin β contributes to collagen deposition in lung fibrosis
por: Biasin, V., et al.
Publicado: (2017)

Origin and Diversification of Meprin Proteases
por: Marín, Ignacio
Publicado: (2015)

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro
por: Bedau, Tillmann, et al.
Publicado: (2017)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
por: Li, Wenjuan, et al.
Publicado: (2010)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
por: Hou, Shurong, et al.
Publicado: (2021)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
por: Wang, Chao, et al.
Publicado: (2021)

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
por: Tan, Kathrin, et al.
Publicado: (2020)

A Systematic Analysis Reveals the Prognostic and Immunological Role of Reptin/RUVBL2 in Human Tumors
por: Su, Xiaoru, et al.
Publicado: (2022)

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis
por: Oneda, Beatrice, et al.
Publicado: (2008)

Evaluation of (¹¹¹)In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers
por: Jodal, Andreas, et al.
Publicado: (2015)

New links for meprin β within the protease web
por: Canbay, Vahap, et al.
Publicado: (2022)

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
por: Bülck, Cynthia, et al.
Publicado: (2023)

TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription
por: Dalvai, Mathieu, et al.
Publicado: (2013)

An old enzyme with a new function: purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin
Publicado: (1994)

Proteolytic processing and inactivation of CCL2/MCP-1 by meprins
por: Herzog, Christian, et al.
Publicado: (2016)

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α(2)
por: Schütte, André, et al.
Publicado: (2010)

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
por: Lottaz, Daniel, et al.
Publicado: (2011)

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
por: Arnold, Philipp, et al.
Publicado: (2017)

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
por: Gellrich, Antonin, et al.
Publicado: (2021)

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion
por: Huguenin, Maya, et al.
Publicado: (2008)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli
por: Vazeille, Emilie, et al.
Publicado: (2011)

Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression
por: Tarangelo, Amy, et al.
Publicado: (2015)

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
por: Lückstädt, Wiebke, et al.
Publicado: (2021)

HPV16 Oncoproteins Promote Cervical Cancer Invasiveness by Upregulating Specific Matrix Metalloproteinases
por: Kaewprag, Jittranan, et al.
Publicado: (2013)

Proceedings: Radioprotective effectivity of alphamercaptopropionylglycine (Thiola, Meprin) and study of its SH activity.
por: Sántha, A., et al.
Publicado: (1975)

A preliminary study of possible fibrotic role of meprin metalloproteases in scleroderma patients
por: Koçak, Ayşe, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3mj002kplti5l02bsbbfvkr6ub