Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8(+)T cell antitumor function

Tumor-induced immune tolerance poses a major challenge for therapeutic interventions aimed to manage cancer. We explored approaches to overcome T-cell suppression in murine breast and kidney adenocarcinomas, and lung fibrosarcoma expressing immunogenic antigens. We observed that treatment with a rev...

Descripción completa

Detalles Bibliográficos
Autores principales: Pellom, Samuel T., Dudimah, Duafalia F., Thounaojam, Menaka C., Uzhachenko, Roman V., Singhal, Ashutosh, Richmond, Ann, Shanker, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352426/
https://www.ncbi.nlm.nih.gov/pubmed/28052005
http://dx.doi.org/10.18632/oncotarget.14365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352426/
https://www.ncbi.nlm.nih.gov/pubmed/28052005
http://dx.doi.org/10.18632/oncotarget.14365

Ejemplares similares