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Release of free amino acids upon oxidation of peptides and proteins by hydroxyl radicals

Hydroxyl radical-induced oxidation of proteins and peptides can lead to the cleavage of the peptide, leading to a release of fragments. Here, we used high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and pre-column online ortho-phthalaldehyde (OPA) derivatization-based ami...

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Detalles Bibliográficos
Autores principales: Liu, Fobang, Lai, Senchao, Tong, Haijie, Lakey, Pascale S. J., Shiraiwa, Manabu, Weller, Michael G., Pöschl, Ulrich, Kampf, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352754/
https://www.ncbi.nlm.nih.gov/pubmed/28108753
http://dx.doi.org/10.1007/s00216-017-0188-y