Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease models still depend upon laborious germline targeting, and are further complicated by the need to avoid developmental phenotypes. We sought to a...

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Detalles Bibliográficos
Autores principales: Jarrett, Kelsey E., Lee, Ciaran M., Yeh, Yi-Hsien, Hsu, Rachel H., Gupta, Rajat, Zhang, Min, Rodriguez, Perla J., Lee, Chang Seok, Gillard, Baiba K., Bissig, Karl-Dimiter, Pownall, Henry J., Martin, James F., Bao, Gang, Lagor, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353616/
https://www.ncbi.nlm.nih.gov/pubmed/28300165
http://dx.doi.org/10.1038/srep44624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353616/
https://www.ncbi.nlm.nih.gov/pubmed/28300165
http://dx.doi.org/10.1038/srep44624

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