S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson’s disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate...

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Detalles Bibliográficos
Autores principales: Kumar, Roshan, Jangir, Deepak K., Verma, Garima, Shekhar, Shashi, Hanpude, Pranita, Kumar, Sanjay, Kumari, Raniki, Singh, Nirpendra, Sarovar Bhavesh, Neel, Ranjan Jana, Nihar, Kanti Maiti, Tushar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353675/
https://www.ncbi.nlm.nih.gov/pubmed/28300150
http://dx.doi.org/10.1038/srep44558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353675/
https://www.ncbi.nlm.nih.gov/pubmed/28300150
http://dx.doi.org/10.1038/srep44558

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