Structural insights into the γ-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans

(+)-γ-lactamase catalyzes the specific hydrolysis of (+)-γ-lactam out of the racemic γ-lactam (2-Azabicyclo[2.2.1]hept-5-en-3-one) to leave optically pure (−)-γ-lactam, which is the key building block of antiviral drugs such as carbovir and abacavir. However, no structural data has been reported on...

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Detalles Bibliográficos
Autores principales: Gao, Shuaihua, Zhou, Yu, Zhang, Weiwei, Wang, Wenhe, Yu, You, Mu, Yajuan, Wang, Hao, Gong, Xinqi, Zheng, Guojun, Feng, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353710/
https://www.ncbi.nlm.nih.gov/pubmed/28295028
http://dx.doi.org/10.1038/srep44542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353710/
https://www.ncbi.nlm.nih.gov/pubmed/28295028
http://dx.doi.org/10.1038/srep44542

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