Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain

Botulinum neurotoxins (BoNTs) are the most toxic proteins known, due to inhibiting the neuronal release of acetylcholine and causing flaccid paralysis. Most BoNT serotypes target neurons by binding to synaptic vesicle proteins and gangliosides via a C-terminal binding sub-domain (H(CC)). However, th...

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Detalles Bibliográficos
Autores principales: Wang, Jiafu, Meng, Jianghui, Nugent, Marc, Tang, Minhong, Dolly, J. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353748/
https://www.ncbi.nlm.nih.gov/pubmed/28295026
http://dx.doi.org/10.1038/srep44474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353748/
https://www.ncbi.nlm.nih.gov/pubmed/28295026
http://dx.doi.org/10.1038/srep44474

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