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Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain
Botulinum neurotoxins (BoNTs) are the most toxic proteins known, due to inhibiting the neuronal release of acetylcholine and causing flaccid paralysis. Most BoNT serotypes target neurons by binding to synaptic vesicle proteins and gangliosides via a C-terminal binding sub-domain (H(CC)). However, th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353748/ https://www.ncbi.nlm.nih.gov/pubmed/28295026 http://dx.doi.org/10.1038/srep44474 |