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Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy
The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side eff...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353927/ https://www.ncbi.nlm.nih.gov/pubmed/28344875 http://dx.doi.org/10.1080/2162402X.2016.1265721 |