Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side eff...

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Detalles Bibliográficos
Autores principales: Lazear, Eric, Ghasemi, Reza, Hein, Sarah M., Westwick, John, Watkins, Dan, Fremont, Daved H., Krupnick, Alexander Sasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353927/
https://www.ncbi.nlm.nih.gov/pubmed/28344875
http://dx.doi.org/10.1080/2162402X.2016.1265721

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