Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional...

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Autores principales: Roos, Abraham B., Mori, Michiko, Gura, Harpreet K., Lorentz, Axel, Bjermer, Leif, Hoffmann, Hans Jürgen, Erjefält, Jonas S., Stampfli, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353957/
https://www.ncbi.nlm.nih.gov/pubmed/28298222
http://dx.doi.org/10.1186/s12931-017-0534-9
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author Roos, Abraham B.
Mori, Michiko
Gura, Harpreet K.
Lorentz, Axel
Bjermer, Leif
Hoffmann, Hans Jürgen
Erjefält, Jonas S.
Stampfli, Martin R.
author_facet Roos, Abraham B.
Mori, Michiko
Gura, Harpreet K.
Lorentz, Axel
Bjermer, Leif
Hoffmann, Hans Jürgen
Erjefält, Jonas S.
Stampfli, Martin R.
author_sort Roos, Abraham B.
collection PubMed
description Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
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spelling pubmed-53539572017-03-22 Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF Roos, Abraham B. Mori, Michiko Gura, Harpreet K. Lorentz, Axel Bjermer, Leif Hoffmann, Hans Jürgen Erjefält, Jonas S. Stampfli, Martin R. Respir Res Letter to the Editor Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling. BioMed Central 2017-03-15 2017 /pmc/articles/PMC5353957/ /pubmed/28298222 http://dx.doi.org/10.1186/s12931-017-0534-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Roos, Abraham B.
Mori, Michiko
Gura, Harpreet K.
Lorentz, Axel
Bjermer, Leif
Hoffmann, Hans Jürgen
Erjefält, Jonas S.
Stampfli, Martin R.
Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title_full Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title_fullStr Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title_full_unstemmed Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title_short Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
title_sort increased il-17ra and il-17rc in end-stage copd and the contribution to mast cell secretion of fgf-2 and vegf
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353957/
https://www.ncbi.nlm.nih.gov/pubmed/28298222
http://dx.doi.org/10.1186/s12931-017-0534-9
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