Cargando…

The structure, dynamics and selectivity profile of a Na(V)1.7 potency-optimised huwentoxin-IV variant

Venom-derived peptides have attracted much attention as potential lead molecules for pharmaceutical development. A well-known example is Huwentoxin-IV (HwTx-IV), a peptide toxin isolated from the venom of the Chinese bird-eating spider Haplopelma schmitdi. HwTx-IV was identified as a potent blocker...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina, Mobli, Mehdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354290/ https://www.ncbi.nlm.nih.gov/pubmed/28301520 http://dx.doi.org/10.1371/journal.pone.0173551

Ejemplares similares

Recombinant Expression and In Vitro Characterisation of Active Huwentoxin-IV
por: Sermadiras, Isabelle, et al.
Publicado: (2013)

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios
por: Lopez, Ludivine, et al.
Publicado: (2021)

Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7
por: Tzakoniati, Foteini, et al.
Publicado: (2020)

Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry
por: Yu, Hai, et al.
Publicado: (2014)

Functional Expression in Escherichia coli of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3
por: Anangi, Raveendra, et al.
Publicado: (2012)

Native Pyroglutamation of Huwentoxin-IV: A Post-Translational Modification that Increases the Trapping Ability to the Sodium Channel
por: Rong, Mingqiang, et al.
Publicado: (2013)

Residual Dipolar Couplings for Resolving Cysteine Bridges in Disulfide-Rich Peptides
por: Ramanujam, Venkatraman, et al.
Publicado: (2020)

Functional Expression of Spider Neurotoxic Peptide Huwentoxin-I in E. coli
por: Meng, Er, et al.
Publicado: (2011)

Aerobic exercise combined with huwentoxin-I mitigates chronic cerebral ischemia injury
por: Mao, Hai-feng, et al.
Publicado: (2017)

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7
por: Yin, Kathleen, et al.
Publicado: (2020)

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH
por: Tran, Poanna, et al.
Publicado: (2023)

Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3
por: Jensen, Jonas E., et al.
Publicado: (2012)

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na(V)1.7
por: McMahon, Kirsten L., et al.
Publicado: (2022)

The thermal probe test: A novel behavioral assay to quantify thermal paw withdrawal thresholds in mice
por: Deuis, Jennifer R., et al.
Publicado: (2016)

Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function
por: Jami, Sina, et al.
Publicado: (2023)

Methods Used to Evaluate Pain Behaviors in Rodents
por: Deuis, Jennifer R., et al.
Publicado: (2017)

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor
por: McMahon, Kirsten L., et al.
Publicado: (2020)

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1
por: Sharma, Gagan, et al.
Publicado: (2021)

Characterization of Synthetic Tf2 as a Na(V)1.3 Selective Pharmacological Probe
por: Israel, Mathilde R., et al.
Publicado: (2020)

Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
por: Klint, Julie K., et al.
Publicado: (2013)

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of Na(V)1.7-Mediated Pain
por: Deuis, Jennifer R., et al.
Publicado: (2016)

Natural Compounds Purified from the Leaves of Aristotelia chilensis: Makomakinol, a New Alkaloid and the Effect of Aristoteline and Hobartine on Na(V) Channels
por: Pérez, Rebeca, et al.
Publicado: (2023)

The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy (15)N-NMR relaxation studies
por: Mobli, Mehdi, et al.
Publicado: (2007)

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target
por: Yin, Kathleen, et al.
Publicado: (2016)

Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a
por: Deuis, Jennifer R., et al.
Publicado: (2017)

Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a
por: Deuis, Jennifer R., et al.
Publicado: (2017)

Development of a high-throughput fluorescent no-wash sodium influx assay
por: Tay, Bryan, et al.
Publicado: (2019)

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel Na(V)1.8 to Enhance Activation
por: Deuis, Jennifer R., et al.
Publicado: (2022)

Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain
por: Nguyen, Phuong T, et al.
Publicado: (2022)

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula
por: Chow, Chun Yuen, et al.
Publicado: (2015)

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers
por: Tran, Hue N.T., et al.
Publicado: (2022)

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network
por: Swedberg, Joakim E., et al.
Publicado: (2011)

Collagen IV differentially regulates planarian stem cell potency and lineage progression
por: Chan, Andy, et al.
Publicado: (2021)

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels
por: Lau, Carus H. Y., et al.
Publicado: (2016)

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System
por: Foster, Victoria S., et al.
Publicado: (2021)

Engineering of a Spider Peptide via Conserved Structure-Function Traits Optimizes Sodium Channel Inhibition In Vitro and Anti-Nociception In Vivo
por: Hu, H., et al.
Publicado: (2021)

Tracking optimisation and the measurement of $K^+ \to \pi^+ \mu^+ \mu^-$ at NA62
por: Sturgess, Andrew
Publicado: (2018)

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists
por: Lucey, Maria, et al.
Publicado: (2020)

Intelligent host engineering for metabolic flux optimisation in biotechnology
por: Munro, Lachlan J., et al.
Publicado: (2021)

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana
por: Shi, Naiqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ocgp7g227lpeltts7fna1hl47d